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KMID : 0043320170400040444
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Archives of Pharmacal Research
2017 Volume.40 No. 4 p.444 ~ p.457
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Design, synthesis and pharmacological analysis of 5-[4′-(substituted-methyl)[1,1′-biphenyl]-2-yl]-1H-tetrazoles
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Kamble Atulkumar
Kamble Ravindra
Dodamani Suneel
Jalalpure Sunil
Rasal Vijaykumar
Kumbar Mahadev
Joshi Shrinivas
Dixit Sheshagiri
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Abstract
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In the present paper 5-[4′-({4-[(4-aryloxy)methyl]-1H-1,2,3-triazol-1-yl}methyl)[1,1′-biphenyl]-2-yl]-1H-tetrazoles (5a?g) and [2′-(1H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl-substituted-1-carbodithioates (11h?q) have been designed and synthesized. These compounds were subjected to docking (against AT1 receptor protein enzyme in complex with Lisinopril), in vitro angiotensin converting enzyme inhibition, anti-proliferative, anti-inflammatory screening (through egg albumin denaturation inhibition and red blood cell membrane stabilization assay) and finally anti-fungal activity analyses. Some of the compounds have shown significant pharmacological properties.
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KEYWORD
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Biphenyl, Tetrazole, Triazole, DTC, ACE inhibition, Anti-proliferative activity, Anti-inflammatory activity, Antifungal activity
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